Research statistics

Pinealon research: publications and trials

What has been published on Pinealon: PubMed publications, the kind of evidence they report and registered clinical trials. These are counts of research, not a judgment of whether Pinealon works or is safe. For what it is and what the studies found, see the Pinealon profile.
Automated weekly refresh · data through November 1, 2026

At a glance

Publications, all years

22

Since 2008

Publications in 2026 so far

0

Through November 1, 2026

Human clinical research

22.7%

5 of 22 classified

Registered clinical trials

0

ClinicalTrials.gov

Randomized controlled trials

0

Publications reporting an RCT in people

Systematic reviews and meta-analyses

0

Preclinical studies

68.2%

12 animal · 3 in vitro · 0 computational

Records that only mention it

2

Not counted above

Status in the library: Research only. Groups: Short peptide bioregulators, Cognitive and neurological peptides, Longevity and mitochondrial peptides.

What to keep in mind

  • Fewer than three randomized controlled trials are indexed.
  • Fewer than 25 publications are indexed, so year-to-year changes are not meaningful.

Publications by year

Pinealon publications by year and evidence

2008, Preclinical (animal, in vitro, computational): 2 of 22011, Preclinical (animal, in vitro, computational): 4 of 42012, Human clinical research: 2 of 42012, Preclinical (animal, in vitro, computational): 2 of 42013, Preclinical (animal, in vitro, computational): 1 of 22013, Reviews and meta-analyses: 1 of 22014, Preclinical (animal, in vitro, computational): 2 of 22015, Human clinical research: 2 of 32015, Preclinical (animal, in vitro, computational): 1 of 32016, Human clinical research: 1 of 12019, Preclinical (animal, in vitro, computational): 1 of 12020, Reviews and meta-analyses: 1 of 12021, Preclinical (animal, in vitro, computational): 1 of 12024, Preclinical (animal, in vitro, computational): 1 of 1Human clinical researchPreclinical (animal, in vitro, computational)Reviews and meta-analyses012342008201320162024
Counted PubMed publications by year of first publication. A larger bar is more publications, not stronger evidence.
Show the data
YearHuman clinical researchPreclinical (animal, in vitro, computational)Reviews and meta-analysesTotal
20080202
20110404
20122204
20130112
20140202
20152103
20161001
20190101
20200011
20210101
20240101

Study types

Animal study12
Other clinical trial4
In vitro study3
Review2
Observational human study1

Research areas

From MeSH major topics. A paper can be in several areas.

Neurological and mental health12
Longevity and aging10
Cognitive health3
Cardiovascular1
Dermatology1
Endocrinology1
Immune system1
Reproductive and sexual health1

Registered clinical trials

A registration is not a result.

No registered trials.

Human trials and evidence reviews

Meta-analyses, systematic reviews and trials in people, newest first.

  1. [Comparative analysis of different methods of geroprotective].

    Advances in gerontology = Uspekhi gerontologii · January 1, 2016 · Other clinical trial · cited 0 times

    PMID 28539017 · Human clinical research

  2. [Assessment of work ability index in evaluation of small peptides geroprotective effect].

    Advances in gerontology = Uspekhi gerontologii · January 1, 2015 · Other clinical trial · cited 0 times

    PMID 28509489 · Human clinical research

  3. [EFFECT OF SYNTHETIC PEPTIDES ON AGING OF PATIENTS WITH CHRONIC POLYMORBIDITY AND ORGANIC BRAIN SYNDROME OF THE CENTRAL NERVOUS SYSTEM IN REMISSION].

    Advances in gerontology = Uspekhi gerontologii · January 1, 2015 · Other clinical trial · cited 1 times

    PMID 26390612 · Human clinical research

  4. [The peptide correction of neurotic disorders among professional truck-drivers].

    Advances in gerontology = Uspekhi gerontologii · January 1, 2012 · Other clinical trial · cited 2 times

    PMID 23734521 · Human clinical research

Most cited

By OpenAlex citation count. Citations measure attention, not quality or correctness.

  1. Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA.

    Biochemistry. Biokhimiia · November 1, 2011 · In vitro study · cited 64 times

    PMID 22117547 · DOI 10.1134/s0006297911110022 · In vitro studies

  2. Optimization of Jiuzao protein hydrolysis conditions and antioxidant activity in vivo of Jiuzao tetrapeptide Asp-Arg-Glu-Leu by elevating the Nrf2/Keap1-p38/PI3K-MafK signaling pathway.

    Food & function · June 1, 2021 · Animal study · cited 51 times

    PMID 33876788 · DOI 10.1039/d0fo02852e · Animal studies

  3. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia.

    International journal of clinical and experimental medicine · April 6, 2012 · Animal study · cited 27 times · open access

    PMID 22567179 · Animal studies

  4. Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes.

    Rejuvenation research · October 6, 2011 · Animal study · cited 17 times

    PMID 21978084 · DOI 10.1089/rej.2011.1172 · Animal studies

  5. EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's Disease.

    Molecules (Basel, Switzerland) · December 31, 2020 · Review · cited 13 times · open access

    PMID 33396470 · DOI 10.3390/molecules26010159 · Reviews and meta-analyses

Latest publications

  1. Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes.

    International journal of molecular sciences · October 22, 2024 · In vitro study · cited 3 times · open access

    PMID 39518916 · DOI 10.3390/ijms252111363 · In vitro studies

  2. Optimization of Jiuzao protein hydrolysis conditions and antioxidant activity in vivo of Jiuzao tetrapeptide Asp-Arg-Glu-Leu by elevating the Nrf2/Keap1-p38/PI3K-MafK signaling pathway.

    Food & function · June 1, 2021 · Animal study · cited 51 times

    PMID 33876788 · DOI 10.1039/d0fo02852e · Animal studies

  3. EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's Disease.

    Molecules (Basel, Switzerland) · December 31, 2020 · Review · cited 13 times · open access

    PMID 33396470 · DOI 10.3390/molecules26010159 · Reviews and meta-analyses

  4. Role of Mono- and Divalent Ions in Peptide Glu-Asp-Arg-DNA Interaction.

    The journal of physical chemistry. B · February 22, 2019 · Animal study · cited 5 times

    PMID 30762356 · DOI 10.1021/acs.jpcb.8b10359 · Animal studies

  5. [Comparative analysis of different methods of geroprotective].

    Advances in gerontology = Uspekhi gerontologii · January 1, 2016 · Other clinical trial · cited 0 times

    PMID 28539017 · Human clinical research

  6. [Assessment of work ability index in evaluation of small peptides geroprotective effect].

    Advances in gerontology = Uspekhi gerontologii · January 1, 2015 · Other clinical trial · cited 0 times

    PMID 28509489 · Human clinical research

  7. [EFFECT OF SYNTHETIC PEPTIDES ON AGING OF PATIENTS WITH CHRONIC POLYMORBIDITY AND ORGANIC BRAIN SYNDROME OF THE CENTRAL NERVOUS SYSTEM IN REMISSION].

    Advances in gerontology = Uspekhi gerontologii · January 1, 2015 · Other clinical trial · cited 1 times

    PMID 26390612 · Human clinical research

  8. [Pinealon and Cortexin influence on behavior and neurochemical processes in 18-month aged rats within hypoxia and hypothermia].

    Advances in gerontology = Uspekhi gerontologii · January 1, 2015 · Animal study · cited 0 times

    PMID 28509493 · Animal studies

  9. Short peptides stimulate serotonin expression in cells of brain cortex.

    Bulletin of experimental biology and medicine · May 1, 2014 · Animal study · cited 9 times

    PMID 24909721 · DOI 10.1007/s10517-014-2496-y · Animal studies

  10. [Regulation of content of cytokines in blood serum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon].

    Advances in gerontology = Uspekhi gerontologii · January 1, 2014 · Animal study · cited 3 times

    PMID 25051764 · Animal studies

Browse all 22 publications in the dashboard

How this is counted

PubMed records matched by the names below, counted when the peptide is in the title, indexed by MeSH, or confirmed from the abstract. The exact query can be rerun on Europe PMC. Methodology

Search terms: EDR peptide; Pinealon

((TITLE_ABS:"EDR peptide" OR CHEM:"EDR peptide") OR (TITLE_ABS:"Pinealon" OR CHEM:"Pinealon")) AND SRC:MED

Cite this page

Peptide Library. (2026, November 2). Pinealon research statistics (Version weekly-2026-11-01) [Statistic]. Peptide Library. https://bestpeptidecalculator.app/research/peptides/pinealon