Peptide Library

Research statistics

Tuftsin research: publications and trials

What has been published on Tuftsin: PubMed publications, the kind of evidence they report and registered clinical trials. These are counts of research, not a judgment of whether Tuftsin works or is safe. For what it is and what the studies found, see the Tuftsin profile.
Automated weekly refresh · data through November 1, 2026

At a glance

Publications, all years

623

Since 1970

Publications in 2026 so far

7

Through November 1, 2026

Human clinical research

4.8%

27 of 564 classified

Registered clinical trials

0

ClinicalTrials.gov

Randomized controlled trials

2

Publications reporting an RCT in people

Systematic reviews and meta-analyses

0

Preclinical studies

82.4%

334 animal · 120 in vitro · 11 computational

Records that only mention it

83

Not counted above

Status in the library: Research only. 59 publications are not yet classified by study type.

What to keep in mind

  • Fewer than three randomized controlled trials are indexed.
  • More than 70% of the indexed publications are animal, cell or computational studies.
  • The body makes this molecule itself, so much of its literature is physiology rather than research on it as a compound.

Publications by year

Tuftsin publications by year and evidence

1970, Other and not yet classified: 1 of 11972, Other and not yet classified: 3 of 31973, Human clinical research: 1 of 71973, Preclinical (animal, in vitro, computational): 1 of 71973, Reviews and meta-analyses: 1 of 71973, Other and not yet classified: 4 of 71974, Preclinical (animal, in vitro, computational): 1 of 21974, Reviews and meta-analyses: 1 of 21975, Preclinical (animal, in vitro, computational): 1 of 41975, Reviews and meta-analyses: 2 of 41975, Other and not yet classified: 1 of 41976, Preclinical (animal, in vitro, computational): 2 of 71976, Reviews and meta-analyses: 2 of 71976, Other and not yet classified: 3 of 71977, Human clinical research: 1 of 91977, Preclinical (animal, in vitro, computational): 3 of 91977, Reviews and meta-analyses: 1 of 91977, Other and not yet classified: 4 of 91978, Preclinical (animal, in vitro, computational): 4 of 141978, Reviews and meta-analyses: 1 of 141978, Other and not yet classified: 9 of 141979, Human clinical research: 1 of 201979, Preclinical (animal, in vitro, computational): 10 of 201979, Reviews and meta-analyses: 3 of 201979, Other and not yet classified: 6 of 201980, Human clinical research: 1 of 171980, Preclinical (animal, in vitro, computational): 8 of 171980, Reviews and meta-analyses: 1 of 171980, Other and not yet classified: 7 of 171981, Human clinical research: 4 of 251981, Preclinical (animal, in vitro, computational): 14 of 251981, Reviews and meta-analyses: 5 of 251981, Other and not yet classified: 2 of 251982, Preclinical (animal, in vitro, computational): 14 of 171982, Reviews and meta-analyses: 2 of 171982, Other and not yet classified: 1 of 171983, Human clinical research: 2 of 511983, Preclinical (animal, in vitro, computational): 34 of 511983, Reviews and meta-analyses: 7 of 511983, Other and not yet classified: 8 of 511984, Human clinical research: 1 of 221984, Preclinical (animal, in vitro, computational): 11 of 221984, Reviews and meta-analyses: 5 of 221984, Other and not yet classified: 5 of 221985, Preclinical (animal, in vitro, computational): 15 of 191985, Reviews and meta-analyses: 4 of 191986, Preclinical (animal, in vitro, computational): 16 of 221986, Reviews and meta-analyses: 5 of 221986, Other and not yet classified: 1 of 221987, Human clinical research: 1 of 151987, Preclinical (animal, in vitro, computational): 12 of 151987, Reviews and meta-analyses: 1 of 151987, Other and not yet classified: 1 of 151988, Preclinical (animal, in vitro, computational): 13 of 131989, Human clinical research: 1 of 241989, Preclinical (animal, in vitro, computational): 20 of 241989, Reviews and meta-analyses: 2 of 241989, Other and not yet classified: 1 of 241990, Preclinical (animal, in vitro, computational): 20 of 221990, Reviews and meta-analyses: 1 of 221990, Other and not yet classified: 1 of 221991, Human clinical research: 2 of 281991, Preclinical (animal, in vitro, computational): 24 of 281991, Other and not yet classified: 2 of 281992, Human clinical research: 1 of 171992, Preclinical (animal, in vitro, computational): 16 of 171993, Human clinical research: 1 of 141993, Preclinical (animal, in vitro, computational): 13 of 141994, Human clinical research: 1 of 151994, Preclinical (animal, in vitro, computational): 14 of 151995, Preclinical (animal, in vitro, computational): 10 of 111995, Other and not yet classified: 1 of 111996, Human clinical research: 1 of 91996, Preclinical (animal, in vitro, computational): 8 of 91997, Preclinical (animal, in vitro, computational): 8 of 101997, Reviews and meta-analyses: 1 of 101997, Other and not yet classified: 1 of 101998, Human clinical research: 1 of 111998, Preclinical (animal, in vitro, computational): 9 of 111998, Reviews and meta-analyses: 1 of 111999, Human clinical research: 1 of 111999, Preclinical (animal, in vitro, computational): 7 of 111999, Reviews and meta-analyses: 1 of 111999, Other and not yet classified: 2 of 112000, Preclinical (animal, in vitro, computational): 4 of 72000, Reviews and meta-analyses: 3 of 72001, Human clinical research: 1 of 52001, Preclinical (animal, in vitro, computational): 2 of 52001, Reviews and meta-analyses: 2 of 52002, Human clinical research: 2 of 72002, Preclinical (animal, in vitro, computational): 5 of 72003, Preclinical (animal, in vitro, computational): 5 of 52004, Preclinical (animal, in vitro, computational): 5 of 52005, Human clinical research: 2 of 162005, Preclinical (animal, in vitro, computational): 14 of 162006, Preclinical (animal, in vitro, computational): 10 of 102007, Preclinical (animal, in vitro, computational): 6 of 82007, Reviews and meta-analyses: 2 of 82008, Preclinical (animal, in vitro, computational): 4 of 42009, Human clinical research: 1 of 82009, Preclinical (animal, in vitro, computational): 6 of 82009, Reviews and meta-analyses: 1 of 82010, Preclinical (animal, in vitro, computational): 2 of 22011, Preclinical (animal, in vitro, computational): 5 of 52012, Preclinical (animal, in vitro, computational): 8 of 82013, Preclinical (animal, in vitro, computational): 5 of 52014, Preclinical (animal, in vitro, computational): 5 of 62014, Reviews and meta-analyses: 1 of 62015, Preclinical (animal, in vitro, computational): 6 of 62016, Preclinical (animal, in vitro, computational): 6 of 82016, Other and not yet classified: 2 of 82017, Preclinical (animal, in vitro, computational): 5 of 72017, Reviews and meta-analyses: 1 of 72017, Other and not yet classified: 1 of 72018, Preclinical (animal, in vitro, computational): 8 of 92018, Reviews and meta-analyses: 1 of 92019, Preclinical (animal, in vitro, computational): 10 of 122019, Reviews and meta-analyses: 1 of 122019, Other and not yet classified: 1 of 122020, Preclinical (animal, in vitro, computational): 4 of 52020, Other and not yet classified: 1 of 52021, Preclinical (animal, in vitro, computational): 7 of 82021, Reviews and meta-analyses: 1 of 82022, Preclinical (animal, in vitro, computational): 6 of 62023, Preclinical (animal, in vitro, computational): 2 of 22024, Preclinical (animal, in vitro, computational): 2 of 32024, Reviews and meta-analyses: 1 of 32025, Preclinical (animal, in vitro, computational): 8 of 92025, Other and not yet classified: 1 of 92026 (to date), Preclinical (animal, in vitro, computational): 7 of 7Human clinical researchPreclinical (animal, in vitro, computational)Reviews and meta-analysesOther and not yet classified020406019701983199520072026*
Counted PubMed publications by year of first publication. * 2026 runs to November 1, 2026. A larger bar is more publications, not stronger evidence.
Show the data
YearHuman clinical researchPreclinical (animal, in vitro, computational)Reviews and meta-analysesOther and not yet classifiedTotal
197000011
197200033
197311147
197401102
197501214
197602237
197713149
1978041914
19791103620
1980181717
19814145225
19820142117
19832347851
19841115522
19850154019
19860165122
19871121115
19880130013
19891202124
19900201122
19912240228
19921160017
19931130014
19941140015
19950100111
199618009
1997081110
1998191011
1999171211
200004307
200112205
200225007
200305005
200405005
20052140016
20060100010
200706208
200804004
200916108
201002002
201105005
201208008
201305005
201405106
201506006
201606028
201705117
201808109
20190101112
202004015
202107108
202206006
202302002
202402103
202508019
2026 (to date)07007

Study types

Animal study334
In vitro study120
Review61
Not yet classified59
Observational human study15
Computational study11
Editorial, letter or other7
Other clinical trial6
Case report4
Correction or retraction notice4
Randomized controlled trial2

Research areas

From MeSH major topics. A paper can be in several areas.

Immune system306
Antimicrobial and infectious disease110
Oncology76
Neurological and mental health73
Gastrointestinal26
Cardiovascular17
Tissue repair13
Cognitive health11
Musculoskeletal11
Endocrinology8
Reproductive and sexual health7
Metabolic health6

Registered clinical trials

A registration is not a result.

No registered trials.

Human trials and evidence reviews

Meta-analyses, systematic reviews and trials in people, newest first.

  1. [Splenic autotransplantation combined with lower esophagus transaction in the treatment of hepatic cirrhosis induced portal hypertension].

    Zhonghua wai ke za zhi [Chinese journal of surgery] · January 1, 2009 · Randomized controlled trial · cited 1 times

    PMID 19562997 · Human clinical research

  2. The value of partial splenic autotransplantation in patients with portal hypertension: a prospective randomized study.

    Archives of surgery (Chicago, Ill. : 1960) · January 1, 2002 · Randomized controlled trial · cited 13 times

    PMID 11772224 · DOI 10.1001/archsurg.137.1.89 · Human clinical research

  3. Effect of liver transplantation on tuftsin activity and phagocytic activity of neutrophil granulocytes in patients with liver cirrhosis.

    International archives of allergy and immunology · June 16, 2005 · Other clinical trial · cited 6 times · open access

    PMID 15961955 · DOI 10.1159/000086339 · Human clinical research

  4. Autotransplant of spleen tissue in children with schistosomiasis: evaluation of splenic function after splenosis.

    Memorias do Instituto Oswaldo Cruz · January 1, 2001 · Other clinical trial · cited 20 times · open access

    PMID 11586436 · DOI 10.1590/s0074-02762001000900017 · Human clinical research

  5. [Autologous spleen transplantation].

    Orvosi hetilap · January 1, 1993 · Other clinical trial · cited 4 times

    PMID 8421623 · Human clinical research

  6. Tuftsin deficiency in AIDS.

    Lancet (London, England) · January 1, 1991 · Other clinical trial · cited 39 times

    PMID 1670648 · DOI 10.1016/0140-6736(91)93331-3 · Human clinical research

  7. Combined immunotherapy and chemotherapy with tuftsin plus cyclophosphamide in the treatment of non-small-cell carcinoma of the lung.

    Chemioterapia : international journal of the Mediterranean Society of Chemotherapy · June 1, 1987 · Other clinical trial · cited 2 times

    PMID 2855624 · Human clinical research

  8. Toxicology and antitumor activity of tuftsin.

    Annals of the New York Academy of Sciences · January 1, 1983 · Other clinical trial · cited 29 times

    PMID 6370073 · DOI 10.1111/j.1749-6632.1983.tb37111.x · Human clinical research

Most cited

By OpenAlex citation count. Citations measure attention, not quality or correctness.

  1. Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model.

    Surgery · August 1, 1983 · Animal study · cited 506 times

    PMID 6879447 · Animal studies

  2. Reverse turns in peptides and proteins.

    CRC critical reviews in biochemistry · January 1, 1980 · Review · cited 501 times

    PMID 7002463 · DOI 10.3109/10409238009105470 · Reviews and meta-analyses

  3. "Tuftsin": a natural phagocytosis stimulating peptide.

    Nature · November 1, 1970 · Not yet classified · cited 334 times

    PMID 4097539 · DOI 10.1038/228672a0 · Not yet classified

  4. Enhancement of phagocytosis - a newly found activity of substance P residing in its N-terminal tetrapeptide sequence.

    Biochemical and biophysical research communications · June 1, 1980 · Not yet classified · cited 310 times

    PMID 6156684 · DOI 10.1016/0006-291x(80)90581-1 · Not yet classified

  5. Treatment of the adult retina with microglia-suppressing factors retards axotomy-induced neuronal degradation and enhances axonal regeneration in vivo and in vitro.

    The Journal of neuroscience : the official journal of the Society for Neuroscience · February 1, 1993 · Animal study · cited 278 times · open access

    PMID 7678855 · DOI 10.1523/jneurosci.13-02-00455.1993 · Animal studies

Latest publications

  1. Bifunctional Phagocytic Synapse Enhancers Remodel the Tumor Microenvironment to Overcome Immunosuppression.

    Cancer research · September 4, 2026 · Animal study · cited 0 times · open access

    PMID 42696459 · DOI 10.1158/0008-5472.can-25-5578 · Animal studies

  2. An Engineered Multifunctional Fusion Protein Targeting Aβ Oligomers, Microglia and Autophagy Ameliorates Cognitive Deficits and Amyloid Pathology in Alzheimer's Disease Mice.

    Cellular and molecular neurobiology · June 24, 2026 · Animal study · cited 0 times · open access

    PMID 42340476 · DOI 10.1007/s10571-026-01753-3 · Animal studies

  3. Tetrahedral DNA Nanostructure-Based Biomimetic Nanovesicles Attenuate Sepsis-Associated ARDS by Suppressing Glycolysis via the BMAL1/PFKFB3 Axis.

    Advanced science (Weinheim, Baden-Wurttemberg, Germany) · April 20, 2026 · Animal study · cited 4 times · open access

    PMID 42003822 · DOI 10.1002/advs.202523782 · Animal studies

  4. Neuropilin-1-Targeted Cell-Penetrating Tandem Peptide-Drug Conjugate Exhibits Potent In Vivo Antiglioma and Antiangiogenic Activity.

    Journal of medicinal chemistry · April 20, 2026 · Animal study · cited 1 times · open access

    PMID 42009314 · DOI 10.1021/acs.jmedchem.5c03835 · Animal studies

  5. Dual-Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell-Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy.

    Advanced healthcare materials · March 29, 2026 · In vitro study · cited 4 times · open access

    PMID 41906540 · DOI 10.1002/adhm.202504285 · In vitro studies

  6. A glycopeptide hydrogel confers protection and treatment in sepsis via recruitment and training of macrophages.

    Materials today. Bio · March 2, 2026 · Animal study · cited 1 times · open access

    PMID 41852883 · DOI 10.1016/j.mtbio.2026.102989 · Animal studies

  7. Antiproliferative Activity of the New Analogues of Acridine/Acridone With Oligopeptide Derivatives and Molecular Docking With EGFR and Src Kinase.

    Journal of peptide science : an official publication of the European Peptide Society · January 1, 2026 · In vitro study · cited 0 times

    PMID 41382988 · DOI 10.1002/psc.70070 · In vitro studies

  8. Hierarchically Targeting and ROS-Responsive Platform for Diabetic Periodontitis Treatment through Mitochondrial Repair in M1 Macrophages.

    ACS applied materials & interfaces · December 28, 2025 · Animal study · cited 2 times

    PMID 41456216 · DOI 10.1021/acsami.5c20136 · Animal studies

  9. FcγR-targeted tuftsin clusters rejuvenate macrophages in preclinical sepsis-associated secondary infection.

    Science translational medicine · December 24, 2025 · Animal study · cited 6 times

    PMID 41442500 · DOI 10.1126/scitranslmed.adv0313 · Animal studies

  10. Macrophage-targeted amphiphilic peptide nanocarrier for intracellular MRSA infection therapy.

    Colloids and surfaces. B, Biointerfaces · September 19, 2025 · Animal study · cited 1 times

    PMID 40987189 · DOI 10.1016/j.colsurfb.2025.115151 · Animal studies

Browse all 623 publications in the dashboard

How this is counted

PubMed records matched by the names below, counted when the peptide is in the title, indexed by MeSH, or confirmed from the abstract. The exact query can be rerun on Europe PMC. Methodology

Search terms: Taftsin; Thr-Lys-Pro-Arg; Tuftsin

((TITLE_ABS:"Taftsin" OR CHEM:"Taftsin") OR (TITLE_ABS:"Thr-Lys-Pro-Arg" OR CHEM:"Thr-Lys-Pro-Arg") OR (TITLE_ABS:"Tuftsin" OR CHEM:"Tuftsin")) AND SRC:MED

Cite this page

Peptide Library. (2026, November 2). Tuftsin research statistics (Version weekly-2026-11-01) [Statistic]. Peptide Library. https://bestpeptidecalculator.app/research/peptides/tuftsin