Peptide Library

Research statistics

Thymogen (Oglufanide) research: publications and trials

What has been published on Thymogen (Oglufanide): PubMed publications, the kind of evidence they report and registered clinical trials. These are counts of research, not a judgment of whether Thymogen (Oglufanide) works or is safe. For what it is and what the studies found, see the Thymogen (Oglufanide) profile.
Automated weekly refresh · data through November 1, 2026

At a glance

Publications, all years

101

Since 1989

Publications in 2026 so far

0

Through November 1, 2026

Human clinical research

26.1%

23 of 88 classified

Registered clinical trials

3

ClinicalTrials.gov

Randomized controlled trials

4

Publications reporting an RCT in people

Systematic reviews and meta-analyses

0

Preclinical studies

65.9%

50 animal · 8 in vitro · 0 computational

Records that only mention it

25

Not counted above

Status in the library: Research only. Groups: Thymic peptides. 13 publications are not yet classified by study type.

What to keep in mind

  • Some completed trials have neither posted results nor a linked results publication.

Publications by year

Thymogen (Oglufanide) publications by year and evidence

1989, Preclinical (animal, in vitro, computational): 1 of 11990, Human clinical research: 1 of 61990, Preclinical (animal, in vitro, computational): 5 of 61991, Human clinical research: 1 of 61991, Preclinical (animal, in vitro, computational): 4 of 61991, Other and not yet classified: 1 of 61992, Human clinical research: 2 of 41992, Preclinical (animal, in vitro, computational): 2 of 41993, Preclinical (animal, in vitro, computational): 4 of 51993, Other and not yet classified: 1 of 51994, Human clinical research: 2 of 81994, Preclinical (animal, in vitro, computational): 3 of 81994, Other and not yet classified: 3 of 81995, Preclinical (animal, in vitro, computational): 3 of 41995, Other and not yet classified: 1 of 41996, Human clinical research: 3 of 51996, Preclinical (animal, in vitro, computational): 1 of 51996, Other and not yet classified: 1 of 51997, Preclinical (animal, in vitro, computational): 1 of 51997, Other and not yet classified: 4 of 51998, Human clinical research: 2 of 51998, Preclinical (animal, in vitro, computational): 1 of 51998, Other and not yet classified: 2 of 51999, Human clinical research: 1 of 71999, Preclinical (animal, in vitro, computational): 6 of 72000, Human clinical research: 4 of 72000, Preclinical (animal, in vitro, computational): 3 of 72001, Human clinical research: 1 of 42001, Preclinical (animal, in vitro, computational): 1 of 42001, Reviews and meta-analyses: 1 of 42001, Other and not yet classified: 1 of 42002, Preclinical (animal, in vitro, computational): 2 of 22003, Preclinical (animal, in vitro, computational): 1 of 12004, Human clinical research: 3 of 42004, Preclinical (animal, in vitro, computational): 1 of 42006, Preclinical (animal, in vitro, computational): 2 of 22007, Human clinical research: 1 of 22007, Preclinical (animal, in vitro, computational): 1 of 22008, Preclinical (animal, in vitro, computational): 3 of 32010, Human clinical research: 1 of 22010, Reviews and meta-analyses: 1 of 22011, Human clinical research: 1 of 22011, Reviews and meta-analyses: 1 of 22012, Preclinical (animal, in vitro, computational): 2 of 22013, Preclinical (animal, in vitro, computational): 1 of 22013, Reviews and meta-analyses: 1 of 22014, Preclinical (animal, in vitro, computational): 3 of 32016, Preclinical (animal, in vitro, computational): 2 of 22017, Preclinical (animal, in vitro, computational): 1 of 12020, Preclinical (animal, in vitro, computational): 1 of 22020, Reviews and meta-analyses: 1 of 22022, Preclinical (animal, in vitro, computational): 1 of 12023, Preclinical (animal, in vitro, computational): 1 of 12024, Reviews and meta-analyses: 1 of 12025, Preclinical (animal, in vitro, computational): 1 of 1Human clinical researchPreclinical (animal, in vitro, computational)Reviews and meta-analysesOther and not yet classified0246819891996200320122025
Counted PubMed publications by year of first publication. A larger bar is more publications, not stronger evidence.
Show the data
YearHuman clinical researchPreclinical (animal, in vitro, computational)Reviews and meta-analysesOther and not yet classifiedTotal
198901001
199015006
199114016
199222004
199304015
199423038
199503014
199631015
199701045
199821025
199916007
200043007
200111114
200202002
200301001
200431004
200602002
200711002
200803003
201010102
201110102
201202002
201301102
201403003
201602002
201701001
202001102
202201001
202301001
202400101
202501001

Study types

Animal study50
Not yet classified13
Other clinical trial12
In vitro study8
Observational human study6
Review6
Randomized controlled trial4
Case report1
Editorial, letter or other1

Research areas

From MeSH major topics. A paper can be in several areas.

Immune system67
Antimicrobial and infectious disease32
Oncology17
Tissue repair12
Gastrointestinal11
Endocrinology7
Neurological and mental health7
Cardiovascular6
Longevity and aging6
Reproductive and sexual health6
Dermatology5
Metabolic health1

Registered clinical trials

1 of 1 trials completed at least a year before the cutoff have neither posted results nor a linked results publication. A registration is not a result.

Completed: 1 · Terminated: 1 · Unknown status: 1
Phase 1: 1 · Phase 2: 2

TrialStatusPhaseStartedResults
Combination Chemotherapy Plus IM-862 in Treating Patients With Resected Stage III Ovarian Cancer or Primary Peritoneal CancerNCT00017303Unknown statusPhase 22001-01—
Chemotherapy Plus IM-862 in Treating Patients With Metastatic Colorectal CancerNCT00006037 · 18 enrolledTerminatedPhase 21999-11—
IM-862 in Treating Patients With Recurrent Ovarian CancerNCT00003773 · 43 enrolledCompletedPhase 11999-02—

Human trials and evidence reviews

Meta-analyses, systematic reviews and trials in people, newest first.

  1. [Application thymogen for preoperative preparation of elderly patients with tumor processes in abdominal cavity].

    Advances in gerontology = Uspekhi gerontologii · January 1, 2011 · Randomized controlled trial · cited 3 times

    PMID 21957588 · Human clinical research

  2. Employing the treatment-free interval of intermittent androgen ablation to screen candidate prostate cancer therapies.

    The Prostate · November 1, 2007 · Randomized controlled trial · cited 6 times

    PMID 17879948 · DOI 10.1002/pros.20649 · Human clinical research

  3. Angiogenesis inhibitor IM862 is ineffective against AIDS-Kaposi's sarcoma in a phase III trial, but demonstrates sustained, potent effect of highly active antiretroviral therapy: from the AIDS Malignancy Consortium and IM862 Study Team.

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology · December 14, 2004 · Randomized controlled trial · cited 47 times · open access

    PMID 15598977 · DOI 10.1200/jco.2005.11.043 · Human clinical research

  4. Results of a randomized study of IM862 nasal solution in the treatment of AIDS-related Kaposi's sarcoma.

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology · February 1, 2000 · Randomized controlled trial · cited 74 times

    PMID 10673512 · DOI 10.1200/jco.2000.18.4.716 · Human clinical research

  5. [Possibilities of the application of antioxidants and antihypoxants in a complex therapy of obsessive conditions in different mental disorders].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · January 1, 2010 · Other clinical trial · cited 0 times

    PMID 20517227 · Human clinical research

  6. Phase II trial of the antiangiogenic agent IM862 in metastatic renal cell carcinoma.

    British journal of cancer · November 1, 2004 · Other clinical trial · cited 20 times · open access

    PMID 15354209 · DOI 10.1038/sj.bjc.6602126 · Human clinical research

  7. [Immunocorrective effect of cycloferon and thymogen in patients with uterine cancer].

    Likars'ka sprava · October 1, 2000 · Other clinical trial · cited 0 times

    PMID 16786663 · Human clinical research

  8. [Applications of immunomodulators in complex of treatment of the soft tissue purulent wounds].

    Klinichna khirurhiia · October 1, 2000 · Other clinical trial · cited 1 times

    PMID 11247420 · Human clinical research

  9. [The effect of thymogen on the state of immunity in destructive pulmonary tuberculosis].

    Voenno-meditsinskii zhurnal · October 1, 1999 · Other clinical trial · cited 0 times

    PMID 10605346 · Human clinical research

  10. [Use of immunomocorrection in the combined treatment of laryngeal papillomatosis in children].

    Vestnik otorinolaringologii · July 1, 1996 · Other clinical trial · cited 0 times

    PMID 8966869 · Human clinical research

Most cited

By OpenAlex citation count. Citations measure attention, not quality or correctness.

  1. Antiangiogenic treatment enhances photodynamic therapy responsiveness in a mouse mammary carcinoma.

    Cancer research · August 1, 2000 · Animal study · cited 255 times

    PMID 10945611 · Animal studies

  2. Clinical aspects and management of AIDS-related Kaposi's sarcoma.

    European journal of cancer (Oxford, England : 1990) · July 1, 2001 · Review · cited 97 times

    PMID 11423260 · DOI 10.1016/s0959-8049(01)00109-5 · Reviews and meta-analyses

  3. Results of a randomized study of IM862 nasal solution in the treatment of AIDS-related Kaposi's sarcoma.

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology · February 1, 2000 · Randomized controlled trial · cited 74 times

    PMID 10673512 · DOI 10.1200/jco.2000.18.4.716 · Human clinical research

  4. Natural and synthetic thymic peptides as therapeutics for immune dysfunction.

    International journal of immunopharmacology · September 1, 1997 · Not yet classified · cited 59 times

    PMID 9637345 · DOI 10.1016/s0192-0561(97)00058-1 · Not yet classified

  5. Angiogenesis inhibitor IM862 is ineffective against AIDS-Kaposi's sarcoma in a phase III trial, but demonstrates sustained, potent effect of highly active antiretroviral therapy: from the AIDS Malignancy Consortium and IM862 Study Team.

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology · December 14, 2004 · Randomized controlled trial · cited 47 times · open access

    PMID 15598977 · DOI 10.1200/jco.2005.11.043 · Human clinical research

Latest publications

  1. Hepatoprotective Effects of Thymogen Analogues in Hydrazine Hepatopathy in Rats.

    Bulletin of experimental biology and medicine · April 1, 2025 · Animal study · cited 0 times

    PMID 40442470 · DOI 10.1007/s10517-025-06405-y · Animal studies

  2. The First Reciprocal Activities of Chiral Peptide Pharmaceuticals: Thymogen and Thymodepressin, as Examples.

    International journal of molecular sciences · May 6, 2024 · Review · cited 3 times · open access

    PMID 38732260 · DOI 10.3390/ijms25095042 · Reviews and meta-analyses

  3. Reparative and Antioxidant Effects of New Analogues of Immunomodulator Thymogen in Experimental Model of Liver Damage.

    Bulletin of experimental biology and medicine · September 1, 2023 · Animal study · cited 1 times

    PMID 37861903 · DOI 10.1007/s10517-023-05929-5 · Animal studies

  4. Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line.

    International journal of molecular sciences · March 25, 2022 · In vitro study · cited 20 times · open access

    PMID 35408963 · DOI 10.3390/ijms23073607 · In vitro studies

  5. Novel platform for the preparation of synthetic orally active peptidomimetics with hemoregulating activity. II. Hemosuppressor activity of 2,5-diketopiperazine-based cyclopeptides.

    International immunopharmacology · February 10, 2020 · Animal study · cited 16 times

    PMID 32058926 · DOI 10.1016/j.intimp.2020.106185 · Animal studies

  6. [Age features of bioregulatory therapy of dental diseases.]

    Advances in gerontology = Uspekhi gerontologii · January 1, 2020 · Review · cited 2 times

    PMID 32362097 · Reviews and meta-analyses

  7. Effects of tryptophan-containing peptides on angiotensin-converting enzyme activity and vessel tone ex vivo and in vivo.

    European journal of nutrition · January 19, 2017 · Animal study · cited 28 times

    PMID 28102435 · DOI 10.1007/s00394-016-1374-y · Animal studies

  8. Chemical Platform for the Preparation of Synthetic Orally Active Peptidomimetics with Hemoregulating Activity.

    ChemMedChem · July 26, 2016 · Animal study · cited 15 times · open access

    PMID 27457274 · DOI 10.1002/cmdc.201600157 · Animal studies

  9. [THE STUDY OF THE EFFECTS OF ANXYOLYTIC, ANTIOXIDANT, IMMUNOCORRECTOR AND HYPERBARIC OXYGENATION ON THE DYNAMICS OF MAIN BLOOD GAS AND ELECTROLYTE INDICES AND BEHAVIORAL RESPONSE IN EXPERIMENTAL STRESS MODEL].

    Eksperimental'naia i klinicheskaia farmakologiia · January 1, 2016 · Animal study · cited 0 times

    PMID 27455576 · Animal studies

  10. [Sensitivity of patients to immunomodulators in immunodeficiency diseases].

    Klinichna khirurhiia · August 1, 2014 · In vitro study · cited 2 times

    PMID 25417290 · In vitro studies

Browse all 101 publications in the dashboard

How this is counted

PubMed records matched by the names below, counted when the peptide is in the title, indexed by MeSH, or confirmed from the abstract. The exact query can be rerun on Europe PMC. Methodology

Search terms: Glutamyltryptophan; Oglufanide; Thymagen; Thymogen; Timogen

((TITLE_ABS:"Glutamyltryptophan" OR CHEM:"Glutamyltryptophan") OR (TITLE_ABS:"Oglufanide" OR CHEM:"Oglufanide") OR (TITLE_ABS:"Thymagen" OR CHEM:"Thymagen") OR (TITLE_ABS:"Thymogen" OR CHEM:"Thymogen") OR (TITLE_ABS:"Timogen" OR CHEM:"Timogen")) AND SRC:MED

Cite this page

Peptide Library. (2026, November 2). Thymogen (Oglufanide) research statistics (Version weekly-2026-11-01) [Statistic]. Peptide Library. https://bestpeptidecalculator.app/research/peptides/thymogen