Semax research: publications and trials

Status in the library: Research only. Groups: Cognitive and neurological peptides. 3 publications are not yet classified by study type.

• Fewer than three randomized controlled trials are indexed.
• More than 70% of the indexed publications are animal, cell or computational studies.

No registered trials.

1. Functional Connectomic Approach to Studying Selank and Semax Effects.

   Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · January 1, 2020 · Randomized controlled trial · cited 5 times

   PMID 32342318 · DOI 10.1134/s001249662001007x · Human clinical research

2. [The study of chronic partial denervation and quality of life in patients with motor neuron disease treated with semax].

   Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · January 1, 2007 · Randomized controlled trial · cited 2 times

   PMID 18379501 · Human clinical research

3. [Effect of a combined physiotherapeutic approach on changes in functional parameters after endovitreal surgery of rhegmatogenous retinal detachment with a favorable anatomical outcome].

   Vestnik oftalmologii · January 1, 2026 · Other clinical trial · cited 0 times

   PMID 42366656 · DOI 10.17116/oftalma202614203129 · Human clinical research

4. [Results of the application of complex physiotherapeutic neurostimulation in optical neuropathies of various genesis].

   Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury · January 1, 2022 · Other clinical trial · cited 4 times

   PMID 36083821 · DOI 10.17116/kurort20229904272 · Human clinical research

5. Effects of Semax on the Default Mode Network of the Brain.

   Bulletin of experimental biology and medicine · September 17, 2018 · Other clinical trial · cited 6 times

   PMID 30225715 · DOI 10.1007/s10517-018-4234-3 · Human clinical research

6. [The efficacy of semax in the tretament of patients at different stages of ischemic stroke].

   Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · January 1, 2018 · Other clinical trial · cited 24 times

   PMID 29798983 · DOI 10.17116/jnevro20181183261-68 · Human clinical research

7. [The results of the application of the pre-formed physical factors and neuroprotective therapy for the rehabilitative treatment of the patients with diabetic retinopathy].

   Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury · September 1, 2013 · Other clinical trial · cited 1 times

   PMID 24437205 · Human clinical research

8. Therapy of peptic ulcer with semax peptide.

   Bulletin of experimental biology and medicine · July 1, 2002 · Other clinical trial · cited 6 times

   PMID 12459874 · DOI 10.1023/a:1020621124776 · Human clinical research

9. [Semax in the treatment of glaucomatous optic neuropathy in patients with normalized ophthalmic tone].

   Vestnik oftalmologii · July 1, 2001 · Other clinical trial · cited 6 times

   PMID 11569188 · Human clinical research

10. [Evaluation of therapeutic effect of new Russian drug semax in optic nerve disease].

    Vestnik oftalmologii · January 1, 2000 · Other clinical trial · cited 13 times

    PMID 10741256 · Human clinical research

1. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus.

   Brain research · September 22, 2006 · Animal study · cited 57 times

   PMID 16996037 · DOI 10.1016/j.brainres.2006.07.108 · Animal studies

2. Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia.

   Cellular and molecular neurobiology · July 25, 2009 · Animal study · cited 54 times · open access

   PMID 19633950 · DOI 10.1007/s10571-009-9432-0 · Animal studies

3. Rapid induction of neurotrophin mRNAs in rat glial cell cultures by Semax, an adrenocorticotropic hormone analog.

   Neuroscience letters · August 1, 2001 · Animal study · cited 46 times

   PMID 11457573 · DOI 10.1016/s0304-3940(01)01994-2 · Animal studies

4. Natural and hybrid ("chimeric") stable regulatory glyproline peptides.

   Pathophysiology : the official journal of the International Society for Pathophysiology · May 1, 2005 · Review · cited 43 times · open access

   PMID 15837162 · DOI 10.1016/j.pathophys.2004.10.001 · Reviews and meta-analyses

5. Effects of semax and its Pro-Gly-Pro fragment on calcium homeostasis of neurons and their survival under conditions of glutamate toxicity.

   Bulletin of experimental biology and medicine · May 1, 2007 · Animal study · cited 41 times

   PMID 18239779 · DOI 10.1007/s10517-007-0192-x · Animal studies

1. Therapeutic peptides in gerontology: mechanisms and applications for healthy aging.

   Frontiers in aging · April 7, 2026 · Review · cited 4 times · open access

   PMID 42021992 · DOI 10.3389/fragi.2026.1790247 · Reviews and meta-analyses

2. [Changes in retinal light sensitivity and morphometry during surgical treatment of primary glaucoma with physiotherapeutic stimulation].

   Vestnik oftalmologii · January 1, 2026 · Observational human study · cited 0 times

   PMID 42885627 · DOI 10.17116/oftalma202614205148 · Human clinical research

3. [Effect of a combined physiotherapeutic approach on changes in functional parameters after endovitreal surgery of rhegmatogenous retinal detachment with a favorable anatomical outcome].

   Vestnik oftalmologii · January 1, 2026 · Other clinical trial · cited 0 times

   PMID 42366656 · DOI 10.17116/oftalma202614203129 · Human clinical research

4. The Potential of the Peptide Drug Semax and Its Derivative for Correcting Pathological Impairments in the Animal Model of Alzheimer's Disease.

   Acta naturae · October 1, 2025 · Animal study · cited 2 times · open access

   PMID 41479572 · DOI 10.32607/actanaturae.27808 · Animal studies

5. The Effect of Peptide Semax, an ACTH(4-10) Analogue, on Intracellular Calcium Dynamics in Rat Brain Neurons.

   Bulletin of experimental biology and medicine · August 1, 2025 · Animal study · cited 0 times

   PMID 41171324 · DOI 10.1007/s10517-025-06501-z · Animal studies

6. Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice.

   British journal of pharmacology · July 21, 2025 · Animal study · cited 4 times

   PMID 40692165 · DOI 10.1111/bph.70122 · Animal studies

7. Genes That Associated with Action of ACTH-like Peptides with Neuroprotective Potential in Rat Brain Regions with Different Degrees of Ischemic Damage.

   International journal of molecular sciences · June 28, 2025 · Animal study · cited 1 times · open access

   PMID 40650034 · DOI 10.3390/ijms26136256 · Animal studies

8. Semax, a Copper Chelator Peptide, Decreases the Cu(II)-Catalyzed ROS Production and Cytotoxicity of aβ by Metal Ion Stripping and Redox Silencing.

   Bioinorganic chemistry and applications · June 3, 2025 · In vitro study · cited 4 times · open access

   PMID 40496623 · DOI 10.1155/bca/4226220 · In vitro studies

9. ACTH-like Peptides Compensate Rat Brain Gene Expression Profile Disrupted by Ischemia a Day After Experimental Stroke.

   Biomedicines · December 13, 2024 · Animal study · cited 7 times · open access

   PMID 39767736 · DOI 10.3390/biomedicines12122830 · Animal studies

10. Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress.

    European journal of pharmacology · October 21, 2024 · Animal study · cited 4 times

    PMID 39442746 · DOI 10.1016/j.ejphar.2024.177068 · Animal studies

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PubMed records matched by the names below, counted when the peptide is in the title, indexed by MeSH, or confirmed from the abstract. The exact query can be rerun on Europe PMC. Methodology

Search terms: Met-Glu-His-Phe-Pro-Gly-Pro; Semax

((TITLE_ABS:"Met-Glu-His-Phe-Pro-Gly-Pro" OR CHEM:"Met-Glu-His-Phe-Pro-Gly-Pro") OR (TITLE_ABS:"Semax" OR CHEM:"Semax")) AND SRC:MED