Peptide LibraryResearch statistics
Macimorelin research: publications and trials
At a glance
Publications, all years
34
Since 2002
Publications in 2026 so far
3
Through November 1, 2026
Human clinical research
50.0%
17 of 34 classified
Registered clinical trials
6
ClinicalTrials.gov
Randomized controlled trials
7
Publications reporting an RCT in people
Systematic reviews and meta-analyses
0
Preclinical studies
38.2%
10 animal · 3 in vitro · 0 computational
Records that only mention it
13
Not counted above
Status in the library: FDA-approved. Groups: Growth hormone axis.
What to keep in mind
- Some completed trials have neither posted results nor a linked results publication.
- Not a peptide: it is shown for completeness and left out of every peptide total.
Publications by year
Macimorelin publications by year and evidence
Show the data
| Year | Human clinical research | Preclinical (animal, in vitro, computational) | Reviews and meta-analyses | Other and not yet classified | Total |
|---|---|---|---|---|---|
| 2002 | 1 | 0 | 0 | 0 | 1 |
| 2003 | 0 | 1 | 1 | 0 | 2 |
| 2007 | 1 | 0 | 0 | 0 | 1 |
| 2009 | 1 | 0 | 0 | 0 | 1 |
| 2010 | 0 | 1 | 0 | 0 | 1 |
| 2012 | 0 | 1 | 0 | 0 | 1 |
| 2013 | 1 | 2 | 0 | 0 | 3 |
| 2014 | 0 | 1 | 1 | 0 | 2 |
| 2016 | 0 | 2 | 0 | 0 | 2 |
| 2018 | 1 | 0 | 1 | 0 | 2 |
| 2019 | 0 | 1 | 0 | 0 | 1 |
| 2020 | 2 | 0 | 0 | 0 | 2 |
| 2021 | 4 | 2 | 0 | 0 | 6 |
| 2022 | 1 | 0 | 0 | 1 | 2 |
| 2023 | 2 | 0 | 0 | 0 | 2 |
| 2024 | 0 | 1 | 0 | 0 | 1 |
| 2025 | 0 | 1 | 0 | 0 | 1 |
| 2026 (to date) | 3 | 0 | 0 | 0 | 3 |
Study types
| Animal study | 10 |
|---|---|
| Other clinical trial | 7 |
| Randomized controlled trial | 7 |
| In vitro study | 3 |
| Review | 3 |
| Observational human study | 2 |
| Case report | 1 |
| Editorial, letter or other | 1 |
Research areas
From MeSH major topics. A paper can be in several areas.
| Endocrinology | 18 |
|---|---|
| Neurological and mental health | 7 |
| Metabolic health | 6 |
| Obesity and weight management | 4 |
| Cardiovascular | 3 |
| Musculoskeletal | 2 |
| Oncology | 2 |
| Antimicrobial and infectious disease | 1 |
| Gastrointestinal | 1 |
| Immune system | 1 |
| Longevity and aging | 1 |
| Tissue repair | 1 |
Registered clinical trials
1 of 5 trials completed at least a year before the cutoff have neither posted results nor a linked results publication. A registration is not a result.
Completed: 6
Phase not applicable: 1 · Phase 1: 1 · Phase 2: 1 · Phase 3: 3
| Trial | Status | Phase | Started | Results |
|---|---|---|---|---|
| A Research Study of How Well Macimorelin Works to Find Out if Children Have a Lack of Growth Hormone and How Safe it isNCT04786873 · 101 enrolled | Completed | Phase 3 | 2021-11 | — |
| Copeptin After an Oral Stimulation With Macimorelin in Healthy VolunteersNCT03844217 · 28 enrolled | Completed | Phase not applicable | 2019-03 | — |
| Validation of Macimorelin as a Test for Adult Growth Hormone DeficiencyNCT02558829 · 157 enrolled | Completed | Phase 3 | 2015-12 | Posted |
| Pilot Clinical Trial of Repeated Doses of Macimorelin to Assess Safety and Efficacy in Patients With Cancer CachexiaNCT01614990 · 15 enrolled | Completed | Phase 2 | 2012-05 | Posted |
| Investigation of a New, Oral Growth Hormone Secretagogue, AEZS-130 as a Growth Hormone Stimulation Test.NCT00448747 · 101 enrolled | Completed | Phase 3 | 2007-06 | Posted |
| Oral Ghrelin Agonist in Healthy SubjectsNCT00377377 · 42 enrolled | Completed | Phase 1 | 2005-11 | — |
Human trials and evidence reviews
Meta-analyses, systematic reviews and trials in people, newest first.
- Safety, pharmacokinetics, and exploratory efficacy of the oral ghrelin receptor agonist AC01 in heart failure with reduced ejection fraction (GOAL-HF1): a randomised, double-blind, placebo-controlled, phase 1b/2a study.
Lancet (London, England) · June 24, 2026 · Randomized controlled trial · cited 1 times · open access
PMID 42341796 · DOI 10.1016/s0140-6736(26)00904-9 · Human clinical research
- Pilot clinical trial of macimorelin to assess safety and efficacy in patients with cancer cachexia.
Journal of cachexia, sarcopenia and muscle · March 1, 2023 · Randomized controlled trial · cited 16 times · open access
PMID 36860137 · DOI 10.1002/jcsm.13191 · Human clinical research
- Thorough QT/QTc Study Evaluating the Effect of Macimorelin on Cardiac Safety Parameters in Healthy Participants.
Clinical pharmacology in drug development · September 22, 2020 · Randomized controlled trial · cited 3 times · open access
PMID 32961034 · DOI 10.1002/cpdd.872 · Human clinical research
- Safety, tolerability, pharmacokinetics, and pharmacodynamics of macimorelin in healthy adults: Results of a single-dose, randomized controlled study.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · April 15, 2020 · Randomized controlled trial · cited 14 times · open access
PMID 32325373 · DOI 10.1016/j.ghir.2020.101321 · Human clinical research
- Macimorelin as a Diagnostic Test for Adult GH Deficiency.
The Journal of clinical endocrinology and metabolism · August 1, 2018 · Randomized controlled trial · cited 115 times · open access
PMID 29860473 · DOI 10.1210/jc.2018-00665 · Human clinical research
- Effect of food on the pharmacokinetics and pharmacodynamics of an oral ghrelin agonist (ARD-07) in healthy subjects.
Journal of clinical pharmacology · March 17, 2009 · Randomized controlled trial · cited 11 times
PMID 19293342 · DOI 10.1177/0091270008330160 · Human clinical research
- Pharmacokinetics and pharmacodynamic effects of an oral ghrelin agonist in healthy subjects.
The Journal of clinical endocrinology and metabolism · February 6, 2007 · Randomized controlled trial · cited 61 times
PMID 17284637 · DOI 10.1210/jc.2006-2160 · Human clinical research
- Neurophysin-I dynamics upon different pituitary provocation tests in healthy participants.
Endocrine connections · May 11, 2026 · Other clinical trial · cited 0 times · open access
PMID 42041101 · DOI 10.1530/ec-25-0929 · Human clinical research
- The effect of glucose dynamics on plasma copeptin levels upon glucagon, arginine, and macimorelin stimulation in healthy adults : Data from: Glucacop, Macicop, and CARGO study.
Pituitary · June 20, 2022 · Other clinical trial · cited 13 times · open access
PMID 35723775 · DOI 10.1007/s11102-022-01240-0 · Human clinical research
- Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Macimorelin in Children with Suspected Growth Hormone Deficiency: An Open-Label, Group Comparison, Dose-Escalation Trial.
Hormone research in paediatrics · August 26, 2021 · Other clinical trial · cited 16 times · open access
PMID 34438400 · DOI 10.1159/000519232 · Human clinical research
Most cited
By OpenAlex citation count. Citations measure attention, not quality or correctness.
- Macimorelin as a Diagnostic Test for Adult GH Deficiency.
The Journal of clinical endocrinology and metabolism · August 1, 2018 · Randomized controlled trial · cited 115 times · open access
PMID 29860473 · DOI 10.1210/jc.2018-00665 · Human clinical research
- Macimorelin (AEZS-130)-stimulated growth hormone (GH) test: validation of a novel oral stimulation test for the diagnosis of adult GH deficiency.
The Journal of clinical endocrinology and metabolism · April 4, 2013 · Other clinical trial · cited 81 times · open access
PMID 23559086 · DOI 10.1210/jc.2013-1157 · Human clinical research
- Ghrelin stimulation of growth hormone-releasing hormone neurons is direct in the arcuate nucleus.
PloS one · February 11, 2010 · Animal study · cited 76 times · open access
PMID 20161791 · DOI 10.1371/journal.pone.0009159 · Animal studies
- New active series of growth hormone secretagogues.
Journal of medicinal chemistry · March 1, 2003 · Animal study · cited 75 times · open access
PMID 12646029 · DOI 10.1021/jm020985q · Animal studies
- Pharmacokinetics and pharmacodynamic effects of an oral ghrelin agonist in healthy subjects.
The Journal of clinical endocrinology and metabolism · February 6, 2007 · Randomized controlled trial · cited 61 times
PMID 17284637 · DOI 10.1210/jc.2006-2160 · Human clinical research
Latest publications
- Safety, pharmacokinetics, and exploratory efficacy of the oral ghrelin receptor agonist AC01 in heart failure with reduced ejection fraction (GOAL-HF1): a randomised, double-blind, placebo-controlled, phase 1b/2a study.
Lancet (London, England) · June 24, 2026 · Randomized controlled trial · cited 1 times · open access
PMID 42341796 · DOI 10.1016/s0140-6736(26)00904-9 · Human clinical research
- Neurophysin-I dynamics upon different pituitary provocation tests in healthy participants.
Endocrine connections · May 11, 2026 · Other clinical trial · cited 0 times · open access
PMID 42041101 · DOI 10.1530/ec-25-0929 · Human clinical research
- Real-world diagnostic performance of the macimorelin stimulation test in the diagnosis of adult growth hormone deficiency.
Pituitary · March 7, 2026 · Observational human study · cited 1 times
PMID 41793495 · DOI 10.1007/s11102-026-01654-0 · Human clinical research
- Molecular recognition of two approved drugs Macimorelin and Anamorelin by the growth hormone secretagogue receptor.
Acta pharmacologica Sinica · June 20, 2025 · In vitro study · cited 0 times
PMID 40542284 · DOI 10.1038/s41401-025-01606-7 · In vitro studies
- Insights into the Effects of Ligand Binding on Leucyl-tRNA Synthetase Inhibitors for Tuberculosis: In Silico Analysis and Isothermal Titration Calorimetry Validation.
Biomolecules · June 16, 2024 · In vitro study · cited 2 times · open access
PMID 38927114 · DOI 10.3390/biom14060711 · In vitro studies
- Contribution of Dynamic and Genetic Tests for Short Stature Diagnosing: A Case Report.
Diagnostics (Basel, Switzerland) · July 4, 2023 · Case report · cited 2 times · open access
PMID 37443653 · DOI 10.3390/diagnostics13132259 · Human clinical research
- Pilot clinical trial of macimorelin to assess safety and efficacy in patients with cancer cachexia.
Journal of cachexia, sarcopenia and muscle · March 1, 2023 · Randomized controlled trial · cited 16 times · open access
PMID 36860137 · DOI 10.1002/jcsm.13191 · Human clinical research
- Macimorelin Acetate for the Diagnosis of Childhood-onset Growth Hormone Deficiency.
TouchREVIEWS in endocrinology · September 8, 2022 · Editorial, letter or other · cited 3 times · open access
PMID 36694890 · DOI 10.17925/ee.2022.18.2.84 · Commentary and other
- The effect of glucose dynamics on plasma copeptin levels upon glucagon, arginine, and macimorelin stimulation in healthy adults : Data from: Glucacop, Macicop, and CARGO study.
Pituitary · June 20, 2022 · Other clinical trial · cited 13 times · open access
PMID 35723775 · DOI 10.1007/s11102-022-01240-0 · Human clinical research
- Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Macimorelin in Children with Suspected Growth Hormone Deficiency: An Open-Label, Group Comparison, Dose-Escalation Trial.
Hormone research in paediatrics · August 26, 2021 · Other clinical trial · cited 16 times · open access
PMID 34438400 · DOI 10.1159/000519232 · Human clinical research
How this is counted
PubMed records matched by the names below, counted when the peptide is in the title, indexed by MeSH, or confirmed from the abstract. The exact query can be rerun on Europe PMC. Methodology
Search terms: AEZS-130; EP-1572; Macimorelin; Macrilen; Solorel
((TITLE_ABS:"AEZS-130" OR CHEM:"AEZS-130" OR TITLE_ABS:"AEZS130" OR CHEM:"AEZS130") OR (TITLE_ABS:"EP-1572" OR CHEM:"EP-1572" OR TITLE_ABS:"EP1572" OR CHEM:"EP1572") OR (TITLE_ABS:"Macimorelin" OR CHEM:"Macimorelin") OR (TITLE_ABS:"Macrilen" OR CHEM:"Macrilen") OR (TITLE_ABS:"Solorel" OR CHEM:"Solorel")) AND SRC:MED
Cite this page
Peptide Library. (2026, November 2). Macimorelin research statistics (Version weekly-2026-11-01) [Statistic]. Peptide Library. https://bestpeptidecalculator.app/research/peptides/macimorelin