Ipamorelin research: publications and trials

Status in the library: Research only. Groups: Growth hormone axis.

• Fewer than three randomized controlled trials are indexed.
• More than 70% of the indexed publications are animal, cell or computational studies.
• Some completed trials have neither posted results nor a linked results publication.

Completed: 2
Phase 2: 2

1. Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients.

   International journal of colorectal disease · October 21, 2014 · Randomized controlled trial · cited 27 times

   PMID 25331030 · DOI 10.1007/s00384-014-2030-8 · Human clinical research

2. Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers.

   Pharmaceutical research · September 1, 1999 · Randomized controlled trial · cited 28 times

   PMID 10496658 · DOI 10.1023/a:1018955126402 · Human clinical research

3. Determination of growth hormone releasing peptides metabolites in human urine after nasal administration of GHRP-1, GHRP-2, GHRP-6, Hexarelin, and Ipamorelin.

   Drug testing and analysis · April 13, 2015 · Other clinical trial · cited 48 times

   PMID 25869809 · DOI 10.1002/dta.1787 · Human clinical research

1. Ipamorelin, the first selective growth hormone secretagogue.

   European journal of endocrinology · November 1, 1998 · Animal study · cited 100 times

   PMID 9849822 · DOI 10.1530/eje.0.1390552 · Animal studies

2. Determination of growth hormone releasing peptides (GHRP) and their major metabolites in human urine for doping controls by means of liquid chromatography mass spectrometry.

   Analytical and bioanalytical chemistry · February 6, 2011 · In vitro study · cited 97 times

   PMID 21298258 · DOI 10.1007/s00216-011-4702-3 · In vitro studies

3. Growth hormone (GH)-independent stimulation of adiposity by GH secretagogues.

   Biochemical and biophysical research communications · January 1, 2001 · Animal study · cited 88 times

   PMID 11162489 · DOI 10.1006/bbrc.2000.4065 · Animal studies

4. Determination of prohibited, small peptides in urine for sports drug testing by means of nano-liquid chromatography/benchtop quadrupole orbitrap tandem-mass spectrometry.

   Journal of chromatography. A · July 28, 2012 · In vitro study · cited 61 times

   PMID 22901302 · DOI 10.1016/j.chroma.2012.07.022 · In vitro studies

5. Metabolism of growth hormone releasing peptides.

   Analytical chemistry · November 13, 2012 · In vitro study · cited 57 times

   PMID 23101768 · DOI 10.1021/ac302034w · In vitro studies

1. Peptide Supplements and Their Therapeutic Applications in Sports Medicine.

   The American journal of sports medicine · August 11, 2026 · Review · cited 1 times · open access

   PMID 42578445 · DOI 10.1177/03635465261464420 · Reviews and meta-analyses

2. The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.

   Frontiers in endocrinology · June 18, 2026 · Review · cited 1 times · open access

   PMID 42395176 · DOI 10.3389/fendo.2026.1822475 · Reviews and meta-analyses

3. Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance.

   Sports medicine (Auckland, N.Z.) · April 12, 2026 · Review · cited 8 times · open access

   PMID 41966639 · DOI 10.1007/s40279-026-02437-0 · Reviews and meta-analyses

4. Therapeutic peptides in gerontology: mechanisms and applications for healthy aging.

   Frontiers in aging · April 7, 2026 · Review · cited 4 times · open access

   PMID 42021992 · DOI 10.3389/fragi.2026.1790247 · Reviews and meta-analyses

5. Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians.

   The American journal of sports medicine · January 1, 2026 · Review · cited 12 times

   PMID 41476424 · DOI 10.1177/03635465251357593 · Reviews and meta-analyses

6. The growth hormone secretagogue receptor 1a agonists, anamorelin and ipamorelin, inhibit cisplatin-induced weight loss in ferrets: Anamorelin also exhibits anti-emetic effects via a central mechanism.

   Physiology & behavior · July 21, 2024 · Animal study · cited 0 times

   PMID 39043357 · DOI 10.1016/j.physbeh.2024.114644 · Animal studies

7. The influence of ghrelin agonist ipamorelin acetate on the hypothalamic-pituitary-testicular axis in a cichlid fish, Oreochromis mossambicus.

   Animal reproduction science · July 5, 2024 · Animal study · cited 4 times

   PMID 38996787 · DOI 10.1016/j.anireprosci.2024.107550 · Animal studies

8. Attenuation of Visceral and Somatic Nociception by Ghrelin Mimetics.

   Journal of experimental pharmacology · August 5, 2020 · Animal study · cited 3 times · open access

   PMID 32801950 · DOI 10.2147/jep.s249747 · Animal studies

9. Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males.

   Translational andrology and urology · March 1, 2020 · Review · cited 12 times · open access

   PMID 32257855 · DOI 10.21037/tau.2019.11.30 · Reviews and meta-analyses

10. Glycine-modified growth hormone secretagogues identified in seized doping material.

    Drug testing and analysis · September 11, 2018 · Editorial, letter or other · cited 9 times

    PMID 30136411 · DOI 10.1002/dta.2489 · Commentary and other

Browse all 46 publications in the dashboard

PubMed records matched by the names below, counted when the peptide is in the title, indexed by MeSH, or confirmed from the abstract. The exact query can be rerun on Europe PMC. Methodology

Search terms: Aib-His-D-2-Nal-D-Phe-Lys-NH2; Ipamorelin; Ipamorelina; Ipamoreline; Ipamorellin; NNC 26-0161

((TITLE_ABS:"Aib-His-D-2-Nal-D-Phe-Lys-NH2" OR CHEM:"Aib-His-D-2-Nal-D-Phe-Lys-NH2" OR TITLE_ABS:"Aib-His-D2-Nal-D-Phe-Lys-NH2" OR CHEM:"Aib-His-D2-Nal-D-Phe-Lys-NH2" OR TITLE_ABS:"Aib-His-D-2-Nal-D-Phe-Lys-NH 2" OR CHEM:"Aib-His-D-2-Nal-D-Phe-Lys-NH 2") OR (TITLE_ABS:"Ipamorelin" OR CHEM:"Ipamorelin") OR (TITLE_ABS:"Ipamorelina" OR CHEM:"Ipamorelina") OR (TITLE_ABS:"Ipamoreline" OR CHEM:"Ipamoreline") OR (TITLE_ABS:"Ipamorellin" OR CHEM:"Ipamorellin") OR (TITLE_ABS:"NNC 26-0161" OR CHEM:"NNC 26-0161" OR TITLE_ABS:"NNC26-0161" OR CHEM:"NNC26-0161")) AND SRC:MED