Peptide Library

Research statistics

Cortexin research: publications and trials

What has been published on Cortexin: PubMed publications, the kind of evidence they report and registered clinical trials. These are counts of research, not a judgment of whether Cortexin works or is safe. For what it is and what the studies found, see the Cortexin profile.
Automated weekly refresh · data through November 1, 2026

At a glance

Publications, all years

165

Since 1980

Publications in 2026 so far

6

Through November 1, 2026

Human clinical research

54.0%

88 of 163 classified

Registered clinical trials

0

ClinicalTrials.gov

Randomized controlled trials

17

Publications reporting an RCT in people

Systematic reviews and meta-analyses

2

Preclinical studies

33.7%

53 animal · 1 in vitro · 1 computational

Records that only mention it

18

Not counted above

Status in the library: Research only. Groups: Cognitive and neurological peptides. 2 publications are not yet classified by study type.

Publications by year

Cortexin publications by year and evidence

1980, Preclinical (animal, in vitro, computational): 3 of 31988, Preclinical (animal, in vitro, computational): 1 of 11993, Preclinical (animal, in vitro, computational): 1 of 11994, Preclinical (animal, in vitro, computational): 1 of 11996, Preclinical (animal, in vitro, computational): 1 of 11997, Preclinical (animal, in vitro, computational): 1 of 11998, Preclinical (animal, in vitro, computational): 2 of 21999, Human clinical research: 1 of 21999, Preclinical (animal, in vitro, computational): 1 of 22000, Preclinical (animal, in vitro, computational): 2 of 22001, Human clinical research: 1 of 22001, Preclinical (animal, in vitro, computational): 1 of 22002, Human clinical research: 1 of 22002, Preclinical (animal, in vitro, computational): 1 of 22003, Preclinical (animal, in vitro, computational): 1 of 12004, Human clinical research: 1 of 22004, Reviews and meta-analyses: 1 of 22006, Human clinical research: 3 of 42006, Other and not yet classified: 1 of 42007, Human clinical research: 4 of 82007, Preclinical (animal, in vitro, computational): 4 of 82008, Human clinical research: 3 of 32009, Human clinical research: 2 of 52009, Preclinical (animal, in vitro, computational): 3 of 52010, Human clinical research: 5 of 62010, Other and not yet classified: 1 of 62011, Human clinical research: 5 of 102011, Preclinical (animal, in vitro, computational): 5 of 102012, Human clinical research: 4 of 52012, Preclinical (animal, in vitro, computational): 1 of 52013, Human clinical research: 6 of 92013, Preclinical (animal, in vitro, computational): 1 of 92013, Reviews and meta-analyses: 2 of 92014, Human clinical research: 4 of 72014, Preclinical (animal, in vitro, computational): 3 of 72015, Human clinical research: 3 of 62015, Preclinical (animal, in vitro, computational): 2 of 62015, Reviews and meta-analyses: 1 of 62016, Human clinical research: 5 of 82016, Preclinical (animal, in vitro, computational): 3 of 82017, Human clinical research: 3 of 72017, Preclinical (animal, in vitro, computational): 3 of 72017, Reviews and meta-analyses: 1 of 72018, Human clinical research: 4 of 62018, Preclinical (animal, in vitro, computational): 2 of 62019, Human clinical research: 6 of 92019, Preclinical (animal, in vitro, computational): 2 of 92019, Reviews and meta-analyses: 1 of 92020, Human clinical research: 4 of 72020, Preclinical (animal, in vitro, computational): 2 of 72020, Reviews and meta-analyses: 1 of 72021, Human clinical research: 3 of 72021, Preclinical (animal, in vitro, computational): 3 of 72021, Reviews and meta-analyses: 1 of 72022, Human clinical research: 3 of 102022, Preclinical (animal, in vitro, computational): 1 of 102022, Reviews and meta-analyses: 6 of 102023, Human clinical research: 3 of 62023, Preclinical (animal, in vitro, computational): 1 of 62023, Reviews and meta-analyses: 2 of 62024, Human clinical research: 5 of 62024, Reviews and meta-analyses: 1 of 62025, Human clinical research: 4 of 92025, Preclinical (animal, in vitro, computational): 2 of 92025, Reviews and meta-analyses: 3 of 92026 (to date), Human clinical research: 5 of 62026 (to date), Preclinical (animal, in vitro, computational): 1 of 6Human clinical researchPreclinical (animal, in vitro, computational)Reviews and meta-analysesOther and not yet classified051019801999200720142026*
Counted PubMed publications by year of first publication. * 2026 runs to November 1, 2026. A larger bar is more publications, not stronger evidence.
Show the data
YearHuman clinical researchPreclinical (animal, in vitro, computational)Reviews and meta-analysesOther and not yet classifiedTotal
198003003
198801001
199301001
199401001
199601001
199701001
199802002
199911002
200002002
200111002
200211002
200301001
200410102
200630014
200744008
200830003
200923005
201050016
2011550010
201241005
201361209
201443007
201532106
201653008
201733107
201842006
201962109
202042107
202133107
2022316010
202331206
202450106
202542309
2026 (to date)51006

Study types

Animal study53
Other clinical trial51
Observational human study19
Review18
Randomized controlled trial17
Not yet classified2
Case report1
Computational study1
In vitro study1
Meta-analysis1
Systematic review1

Research areas

From MeSH major topics. A paper can be in several areas.

Neurological and mental health136
Cardiovascular62
Cognitive health31
Tissue repair14
Longevity and aging10
Immune system7
Antimicrobial and infectious disease6
Endocrinology3
Metabolic health3
Musculoskeletal2
Reproductive and sexual health2
Obesity and weight management1

Registered clinical trials

A registration is not a result.

No registered trials.

Human trials and evidence reviews

Meta-analyses, systematic reviews and trials in people, newest first.

  1. The efficacy and safety of animal-derived nootropics in cognitive disorders: Systematic review and meta-analysis.

    Cerebral circulation - cognition and behavior · April 16, 2021 · Meta-analysis · cited 12 times · open access

    PMID 36324709 · DOI 10.1016/j.cccb.2021.100012 · Reviews and meta-analyses

  2. Cerebrolysin for acute ischaemic stroke.

    The Cochrane database of systematic reviews · October 11, 2023 · Systematic review · cited 29 times · open access

    PMID 37818733 · DOI 10.1002/14651858.cd007026.pub7 · Reviews and meta-analyses

  3. [Cortexin in the comprehensive treatment of neurological complications of type 2 diabetes mellitus. (Results of the DIACORT multicenter randomized clinical trial)].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · January 1, 2026 · Randomized controlled trial · cited 0 times

    PMID 42133422 · DOI 10.17116/jnevro2026126041101 · Human clinical research

  4. [Therapeutic equivalence of intravenous and intramuscular dosage forms of Cortexin in ischemic strokes].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · January 1, 2025 · Randomized controlled trial · cited 0 times

    PMID 41524350 · DOI 10.17116/jnevro202512512160 · Human clinical research

  5. [The effectiveness of rehabilitation measures using the drug Cortexin in children with neuropsychiatric pathology].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · January 1, 2024 · Randomized controlled trial · cited 1 times

    PMID 39731376 · DOI 10.17116/jnevro202412412186 · Human clinical research

  6. [Comparison of the efficacy of Cellex and Cortexin in patients in the early recovery period of ischemic stroke].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · January 1, 2020 · Randomized controlled trial · cited 1 times

    PMID 33449527 · DOI 10.17116/jnevro202012012211 · Human clinical research

  7. [Potential of peptidergic nootropic therapy in developmental dysphasia in children].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · January 1, 2019 · Randomized controlled trial · cited 2 times

    PMID 31851172 · DOI 10.17116/jnevro201911911147 · Human clinical research

  8. [Dose-dependent effects of cortexin in chronic cerebral ischemia (results of a multicenter randomized controlled study)].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · January 1, 2018 · Randomized controlled trial · cited 25 times

    PMID 30335070 · DOI 10.17116/jnevro201811809135 · Human clinical research

  9. [Clinical efficacy and pharmacoeconomic characteristics of the neuroprotection with low doses of cortexin in the treatment of acute ischemic stroke].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · January 1, 2014 · Randomized controlled trial · cited 8 times

    PMID 24874316 · Human clinical research

  10. Effects of neuroprotector cortexin on the dynamics of neuroendocrine system parameters in patients with organic emotionally labile (asthenic) disorders.

    Bulletin of experimental biology and medicine · May 1, 2013 · Randomized controlled trial · cited 2 times

    PMID 23667876 · DOI 10.1007/s10517-013-2083-7 · Human clinical research

Most cited

By OpenAlex citation count. Citations measure attention, not quality or correctness.

  1. [Cortexin. Molecular mechanisms and targets of neuroprotective activity].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · January 1, 2015 · Review · cited 52 times

    PMID 26356623 · DOI 10.17116/jnevro20151158199-104 · Reviews and meta-analyses

  2. Neuroprotective action of Cortexin, Cerebrolysin and Actovegin in acute or chronic brain ischemia in rats.

    PloS one · July 14, 2021 · Animal study · cited 37 times · open access

    PMID 34260655 · DOI 10.1371/journal.pone.0254493 · Animal studies

  3. Cerebrolysin for acute ischaemic stroke.

    The Cochrane database of systematic reviews · October 11, 2023 · Systematic review · cited 29 times · open access

    PMID 37818733 · DOI 10.1002/14651858.cd007026.pub7 · Reviews and meta-analyses

  4. [Determination of the prevalence of postcovid syndrome and assessment of the effectiveness of the drug Cortexin in the treatment of neurological disorders in patients with postcovid syndrome. Results of the multicenter clinical and epidemiological observational program CORTEX].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · January 1, 2022 · Observational human study · cited 28 times

    PMID 35175707 · DOI 10.17116/jnevro202212201184 · Human clinical research

  5. [A multicenter observation study of the efficacy of cortexin and recognan (citicoline) in the treatment of cognitive impairments in chronic cerebrovascular pathology].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · January 1, 2019 · Other clinical trial · cited 26 times

    PMID 30874524 · DOI 10.17116/jnevro201911902135 · Human clinical research

Latest publications

  1. [The effect of neuroprotectors on the level of BDNF, tumor necrosis factor alpha and apoptosis markers, and in acute cerebrovascular accidents].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · January 1, 2026 · Animal study · cited 0 times

    PMID 41782540 · DOI 10.17116/jnevro2026126021123 · Animal studies

  2. [Evaluation of the efficiency of combined neuroprotection and high-intensity magnetotherapy in the medical rehabilitation of patients with ischemic stroke].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · January 1, 2026 · Observational human study · cited 0 times

    PMID 42246531 · DOI 10.17116/jnevro202612605188 · Human clinical research

  3. [Neurocognitive characteristics in children with sluggish cognitive tempo].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · January 1, 2026 · Other clinical trial · cited 0 times

    PMID 42899917 · DOI 10.17116/jnevro202612609152 · Human clinical research

  4. [Efficacy and safety of Cortexin as additional therapy in patients with depressive disorder].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · January 1, 2026 · Other clinical trial · cited 0 times

    PMID 41782536 · DOI 10.17116/jnevro202612602192 · Human clinical research

  5. [Cortexin in the comprehensive treatment of neurological complications of type 2 diabetes mellitus. (Results of the DIACORT multicenter randomized clinical trial)].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · January 1, 2026 · Randomized controlled trial · cited 0 times

    PMID 42133422 · DOI 10.17116/jnevro2026126041101 · Human clinical research

  6. [Cortexin in the comprehensive therapy of alcoholic encephalopathy].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · January 1, 2026 · Other clinical trial · cited 0 times

    PMID 42360215 · DOI 10.17116/jnevro202612606152 · Human clinical research

  7. Use of nootropics in Alzheimer's disease: An analysis of regulatory positions and drug policies in the countries of the Commonwealth of Independent States.

    The International journal of risk & safety in medicine · December 30, 2025 · Review · cited 0 times

    PMID 41467376 · DOI 10.1177/09246479251410817 · Reviews and meta-analyses

  8. Cortexin modulates OPG/RANK/RANKL and TRPC1 expression in cerebral ischemia-reperfusion injury.

    Neurological research · August 10, 2025 · Animal study · cited 0 times

    PMID 40783844 · DOI 10.1080/01616412.2025.2536075 · Animal studies

  9. Neurotropic Effects of Cortexin on Models of Mental and Physical Developmental Delay.

    Biomedicines · April 2, 2025 · Animal study · cited 1 times · open access

    PMID 40299434 · DOI 10.3390/biomedicines13040860 · Animal studies

  10. [The role of genetic polymorphisms in folate metabolism genes in the manifestation of migraine in children].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · January 1, 2025 · Observational human study · cited 1 times

    PMID 39930676 · DOI 10.17116/jnevro202512501147 · Human clinical research

Browse all 165 publications in the dashboard

How this is counted

PubMed records matched by the names below, counted when the peptide is in the title, indexed by MeSH, or confirmed from the abstract. The exact query can be rerun on Europe PMC. Methodology

Search terms: Cerebral cortex polypeptide; Cortexin; Kortexin

((TITLE_ABS:"Cerebral cortex polypeptide" OR CHEM:"Cerebral cortex polypeptide") OR (TITLE_ABS:"Cortexin" OR CHEM:"Cortexin") OR (TITLE_ABS:"Kortexin" OR CHEM:"Kortexin")) AND SRC:MED

Cite this page

Peptide Library. (2026, November 2). Cortexin research statistics (Version weekly-2026-11-01) [Statistic]. Peptide Library. https://bestpeptidecalculator.app/research/peptides/cortexin